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AQP1 / Aquaporin 1 Antibody
Rabbit Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, IHC-P, IF |
|---|---|
| Primary Accession | P29972 |
| Reactivity | Human, Mouse, Rat |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 29kDa |
| Dilution | IF (1:200-1:400), IHC-P (10 µg/ml), WB (1:1000-1:4000) |
| Gene ID | 358 |
|---|---|
| Other Names | Aquaporin-1, AQP-1, Aquaporin-CHIP, Urine water channel, Water channel protein for red blood cells and kidney proximal tubule, AQP1, CHIP28 |
| Target/Specificity | Detects ~28.5kDa.Glycosylated bands ~35-50kDa. |
| Reconstitution & Storage | Short term 4°C, long term aliquot and store at -20°C, avoid freeze thaw cycles. |
| Precautions | AQP1 / Aquaporin 1 Antibody is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | AQP1 (HGNC:633) |
|---|---|
| Function | Forms a water channel that facilitates the transport of water across cell membranes, playing a crucial role in water homeostasis in various tissues (PubMed:1373524, PubMed:23219802). Could also be permeable to small solutes including hydrogen peroxide, glycerol and gases such as amonnia (NH3), nitric oxide (NO) and carbon dioxide (CO2) (PubMed:16682607, PubMed:17012249, PubMed:19273840, PubMed:33028705, PubMed:8584435). Recruited to the ankyrin-1 complex, a multiprotein complex of the erythrocyte membrane, it could be part of a CO2 metabolon, linking facilitated diffusion of CO2 across the membrane, anion exchange of Cl(-)/HCO3(-) and interconversion of dissolved CO2 and carbonic acid in the cytosol (PubMed:17012249, PubMed:35835865). In vitro, it shows non-selective gated cation channel activity and may be permeable to cations like K(+) and Na(+) in vivo (PubMed:36949749, PubMed:8703053). |
| Cellular Location | Cell membrane; Multi-pass membrane protein |
| Tissue Location | Detected in erythrocytes (at protein level). Expressed in a number of tissues including erythrocytes, renal tubules, retinal pigment epithelium, heart, lung, skeletal muscle, kidney and pancreas. Weakly expressed in brain, placenta and liver |
| Volume | 50 µl |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
Forms a water-specific channel that provides the plasma membranes of red cells and kidney proximal tubules with high permeability to water, thereby permitting water to move in the direction of an osmotic gradient.
References
Preston G.M.,et al.Proc. Natl. Acad. Sci. U.S.A. 88:11110-11114(1991).
Moon C.,et al.J. Biol. Chem. 268:15772-15778(1993).
Ruiz A.C.,et al.Biochim. Biophys. Acta 1282:174-178(1996).
Li X.,et al.Biochem. Mol. Biol. Int. 32:371-377(1994).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
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